Table 2.

13 SNPs showing evidence of a sex-specific effect in disease association using PMASE

Disease	SNP	Combined p value	Female p value	Male p value	Combined OR	Female OR	Male OR	PMASE p value	Q-value	Gene
CAD	rs7865618	1.57 × 10−8	0.167	1.38 × 10−8	1.290	1.161	1.381	0.0214	0.053
CD	rs3792106	4.77 × 10 −12	6.85 × 10 −13	0.0134	1.346	1.477	1.223	0.0019	0.04	ATG16L1
	rs6431654	7.75 × 10−14	1.15 × 10−12	0.00208	1.385	1.511	1.255	0.0101	0.18	ATG16L1
RA	rs3134926	8.03 × 10−22	1.02 × 10−18	0.000137	1.645	1.773	1.439	0.0296	1
	rs4947244	6.70 × 10−8	2.95 × 10−8	0.250	1.292	1.344	1.140	0.0127	1	HLA-G
	rs3132666	7.00 × 10−8	1.57 × 10−8	0.0526	0.789	0.745	0.864	0.0225	1
T1D	rs2763979	9.90 × 10−61	1.73 × 10−41	1.81 × 10−21	0.497	0.438	0.562	0.0031	1	HSPA1B
	rs4148873	2.78 × 10−24	1.30 × 10−7	9.15 × 10−19	1.976	1.664	2.381	0.0088	1	TAP2
	rs3131622	6.49 × 10−12	1.92 × 10−10	0.00197	0.745	0.676	0.820	0.0226	1
	rs480092	8.41 × 10−15	1.31 × 10−12	0.000212	1.511	1.695	1.348	0.0191	1	VARS
	rs3134926	8.19 × 10−10	7.68 × 10−9	0.00817	1.361	1.517	1.224	0.0285	1
	rs12660883	1.54 × 10−12	0.000573	2.55 × 10−10	0.626	0.708	0.551	0.0371	1
	rs2734973	2.08 × 10−11	2.69 × 10−9	0.0013	1.64	1.88	1.43	0.0470	1

The 13 SNPs with significant sex-difference p values (PMASE p value <0.05) out of the original 280 SNPs are shown below. The allelic odds ratios (OR) are calculated with respect to the risk allele. rs2734973 (italicized) was later excluded after inspection of the intensity plot