Table 2.
13 SNPs showing evidence of a sex-specific effect in disease association using PMASE
| Disease | SNP | Combined p value | Female p value | Male p value | Combined OR | Female OR | Male OR | PMASE p value | Q-value | Gene |
|---|---|---|---|---|---|---|---|---|---|---|
| CAD | rs7865618 | 1.57 × 10−8 | 0.167 | 1.38 × 10−8 | 1.290 | 1.161 | 1.381 | 0.0214 | 0.053 | |
| CD | rs3792106 | 4.77 × 10 −12 | 6.85 × 10 −13 | 0.0134 | 1.346 | 1.477 | 1.223 | 0.0019 | 0.04 | ATG16L1 |
| rs6431654 | 7.75 × 10−14 | 1.15 × 10−12 | 0.00208 | 1.385 | 1.511 | 1.255 | 0.0101 | 0.18 | ATG16L1 | |
| RA | rs3134926 | 8.03 × 10−22 | 1.02 × 10−18 | 0.000137 | 1.645 | 1.773 | 1.439 | 0.0296 | 1 | |
| rs4947244 | 6.70 × 10−8 | 2.95 × 10−8 | 0.250 | 1.292 | 1.344 | 1.140 | 0.0127 | 1 | HLA-G | |
| rs3132666 | 7.00 × 10−8 | 1.57 × 10−8 | 0.0526 | 0.789 | 0.745 | 0.864 | 0.0225 | 1 | ||
| T1D | rs2763979 | 9.90 × 10−61 | 1.73 × 10−41 | 1.81 × 10−21 | 0.497 | 0.438 | 0.562 | 0.0031 | 1 | HSPA1B |
| rs4148873 | 2.78 × 10−24 | 1.30 × 10−7 | 9.15 × 10−19 | 1.976 | 1.664 | 2.381 | 0.0088 | 1 | TAP2 | |
| rs3131622 | 6.49 × 10−12 | 1.92 × 10−10 | 0.00197 | 0.745 | 0.676 | 0.820 | 0.0226 | 1 | ||
| rs480092 | 8.41 × 10−15 | 1.31 × 10−12 | 0.000212 | 1.511 | 1.695 | 1.348 | 0.0191 | 1 | VARS | |
| rs3134926 | 8.19 × 10−10 | 7.68 × 10−9 | 0.00817 | 1.361 | 1.517 | 1.224 | 0.0285 | 1 | ||
| rs12660883 | 1.54 × 10−12 | 0.000573 | 2.55 × 10−10 | 0.626 | 0.708 | 0.551 | 0.0371 | 1 | ||
| rs2734973 | 2.08 × 10−11 | 2.69 × 10−9 | 0.0013 | 1.64 | 1.88 | 1.43 | 0.0470 | 1 |
The 13 SNPs with significant sex-difference p values (PMASE p value <0.05) out of the original 280 SNPs are shown below. The allelic odds ratios (OR) are calculated with respect to the risk allele. rs2734973 (italicized) was later excluded after inspection of the intensity plot