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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Oral Dis. 2011 Oct 24;18(2):121–126. doi: 10.1111/j.1601-0825.2011.01863.x

Table 1.

Biomarker discovery using large scale inventorying technologies.

Technology Findings Reference
Gene Array Gene array profiling of SjS patients identifies an “interferon signature” that includes up-regulated genes such as TLR8, IFITM1, and BAFF. Bave et al, 2005; Gottenberg et al, 2006; Hjelmervik et al, 2005
Relative expression of an eight-gene panel identifies SjS patients with a favorable response to anti-CD20 antibody therapy. Devauchelle-Pensec et al, 2010
MicroRNA Array The ratio of two microRNA (has-miR-768-3p, and has-miR-574) from gland biopsies predicts increased salivary inflammation. Alevizos et al, 2011
Metagenomics High levels of Porphyromonas catoniae and Neiseerira flavescens in the oral cavity are associated with a lack of dental caries. Crielaard et al, 2011
Proteomics SjS patients show altered protein composition of saliva Hu et al, 2007; Ryu et al, 2006
Antigen Array Salivary autoantibodies against 24 proteins distinguished SjS from SLE and controls. Hu et al, 2011