Fig. 5.

Comparison of the mucoadhesive properties of unmodified, thiolated and pre-activated poly acrylates with an average molecular mass of A: 100 kDa; B: 250 kDa and C: 450 kDa as determined by the rotating cylinder method. Thirty milligrams polymer tablets were attached to excised porcine intestinal mucosa, which was spanned on a vertical cylinder rotated with 100 rpm in 100 mm phosphate buffer pH 6.8 at 37 °C. The indicated time of adhesion represents an average of at least three experiments (±S.D.). A₁ differs from A₂p = 0.0023; B₁ differs from B₂p = 0.0067; C₁ differs from C₂p = 0.0145.