Table 1.
Comparison of the total work of adhesion (TWA), maximum detachment force (MDF) and improvement ratios (indicated polymer/corresponding unmodified polymer) of 30 mg tablets consisting of PAA-cysteine (100-, 250- and 450 kDa) and PAA-cys-2MNA (100-, 250- and 450 kDa) in comparison to corresponding unmodified polymers. Indicated values are mean ± S.D. of at least three experiments.
| Tested polymers | TWA (μJ) | Improvement ratio | MDF (mN) | Improvement ratio |
|---|---|---|---|---|
| unmodified PAA (100 kDa) | 25.7 ± 3.0 | – | 18.8 ± 3.0 | – |
| PAA-cysteine (100 kDa) | 75.4 ± 9.5 | 2.9 | 102.1 ± 6.4 | 5.4 |
| PAA-cysteine-2MNA (100 kDa) | 152.2 ± 44.3 | 5.9 | 129.1 ± 2.0 | 6.8 |
| unmodified PAA (250 kDa) | 47.3 ± 7.9 | – | 26.6 ± 8.1 | – |
| PAA-cysteine (250 kDa) | 98.5 ± 3.9 | 2.1 | 111.6 ± 6.3 | 4.2 |
| PAA-cysteine-2MNA (250 kDa) | 189.5 ± 7.5 | 4.0 | 144.8 ± 39.5 | 5.4 |
| unmodified PAA (450 kDa) | 106.9 ± 13.2 | – | 92.7 ± 19.3 | – |
| PAA-cysteine (450 kDa) | 202.2 ± 24.3 | 1.9 | 131.1 ± 2.0 | 1.4 |
| PAA-cysteine-2MNA (450 kDa) | 325.7 ± 36.6 | 3.0 | 233.8 ± 8.7 | 2.5 |