Table 2.
Comparison of the apparent viscocity (η) of PAA-cysteine (100-, 250- and 450 kDa) and PAA-cys-2MNA (100-, 250- and 450 kDa) in comparison to corresponding unmodified polymers. Indicated values are mean ± S.D. of at least three experiments.
| Tested polymers | Apparent viscosity [η (mPas)] |
|||
|---|---|---|---|---|
| Without mucin (a) |
With mucin (b) |
|||
| At time point “0” | After 0.5 h | After 6 h | After 24 h | |
| unmodified PAA (100 kDa) | 10 ± 4 | 10 ± 4 | 10 ± 2 | 10 ± 2 |
| PAA-cysteine (100 kDa) | 16 ± 4 | 20 ± 5 | 20 ± 2 | 30 ± 5 |
| PAA-cysteine-2MNA (100 kDa) | 50 ± 10 | 50 ± 10 | 55 ± 10 | 70 ± 10 |
| unmodified PAA (250 kDa) | 12 ± 4 | 24 ± 2 | 23 ± 3 | 23 ± 4 |
| PAA-cysteine (250 kDa) | 27 ± 5 | 50 ± 30 | 70 ± 10 | 140 ± 30 |
| PAA-cysteine-2MNA (250 kDa) | 80 ± 10 | 287 ± 49 | 318 ± 69 | 434 ± 69 |
| unmodified PAA (450 kDa) | 26 ± 2 | 63 ± 10 | 61 ± 2 | 62 ± 2 |
| PAA-cysteine (450 kDa) | 6020 ± 281 | 7982 ± 405 | 17027 ± 719 | 19458 ± 1852 |
| PAA-cysteine-2MNA (450 kDa) | 12860 ± 400 | 35870 ± 1942 | 58872 ± 3227 | 166033 ± 24017 |