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. 2011 Sep 6;23(1):83–90. doi: 10.1089/hum.2011.091

FIG. 4.

FIG. 4.

INVOp supports stable LEKTI expression. (A) Schematic view of the INVOp-SPINK5co sites susceptible to CpG methylation. (B) NTERT cells transduced with INVOp-SP/GFP were cultured in the presence or absence of 5 μM azacitidine (aza) for a period of 39 days. GFP intensity did not change in the first 11 days, but was increased following day 11. This is likely to be a result of enhanced involucrin expression during keratinocyte differentiation. (C) The proportion of GFP-positive cells remained stable in the presence/absence of azacitidine treatment. (D) Western blot analysis with anti-LEKTI antibody shows stable LEKTI expression in NTERT cells transduced with INVOp-SP/GFP over time.