Table 1.
Virus | PP/mla(× 1012) | PP/PFUa |
---|---|---|
Ad[WT] | 2.9±0.7 | 50±31 |
Ad[ZH/1] | 1.8±0.8 | 140±23 |
Ad[ZH/2] | 2.1±0.2 | 805±162 |
Ad[ZH/3] | 1.6±1.4 | 620±202 |
Ad[ZH/1], Her2/neu-targeted and CAR-detargeted virus; Ad[ZH/2], virus with ablation of CAR binding and mutation of RKSK; Ad[ZH/3], virus with mutation of all three binding structures; PFU, plaque-forming unit; PP, physical particles; WT, wild type.
Measurements from two or three different CsCℓ purifications of 10 infected 175-cm2 flasks, displayed as the average±SD.