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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2012 Jan;18(1 Suppl):S46–S52. doi: 10.1016/j.bbmt.2011.10.021

Table 1.

Proposed Modifications to NIH BOS Clinical Definition (adapted from (14))

Absence of infection (No Change)
Another cGVHD manifestation in another organ (No Change)
FEV1 < 75% predicted (No Change) or > 10% decline from pre-HCT value (Modification)
Signs of Obstruction
   

  • FEV1/SVC ratio < 0.7 (Modification), or

  • RV > 120% predicted (No Change), or

  • RV/TLC > 120% (Modification), and

  • HRCT with evidence of air trapping (No Change)

NIH: National Institutes of Health; BOS: bronchiolitis obliterans syndrome; cGVHD: chronic graft-versus-host disease; FEV1: forced expiratory volume in 1 second; ; SVC: slow vital capacity; RV: residual volume; TLC, total lung capacity; HRCT: high-resolution computed tomography.