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. Author manuscript; available in PMC: 2012 Jan 18.
Published in final edited form as: Cell Cycle. 2008 Feb 27;7(9):1151–1156. doi: 10.4161/cc.7.9.5817

Fig. 3. Intermolecular contact in the p110α /p85 heterodimer crystal.

Fig. 3

(A) Molecular surface of the PI3K colored as electrostatic charges showing the Ras binding domain of a neighboring molecule in the crystal (orange ribbon with black back-side) bound in the kinase domain active site. (B) Molecular surface colored as electrostatic potential showing the ATP (ball-and-stick representation) bound to PI3Kα . (C) Molecular surface colored according to the electrostatic potential showing the helix-loop-helix motif of the RBD of the neighboring molecule in the ATP binding site.