Figure 3.

Young and old F344BN rats were fed rapamycin for 3 weeks or were given a regimen of intermittent (every other day) calorie restriction (IF). IF- and rapamycin-treated animals lost approximately 15% of their body weight relative to controls. Moreover, the young IF animals lost more weight than their rapamycin-fed counterparts (lower panel). There was an effect of age on the memory test (upper right); however, rapamycin had no impact on cognitive function, although physical activity was increased with treatment, regardless of age (*all ps < .05).