Affiliation of ‘Candidatus Steffania adelgidicola' proteins to NCBI COGs and occurrence of homologs in the genomes of E. coli and other insect symbionts. Gray boxes indicate the presence of homologs (E-value <10−9, except for pseudogenes); white indicates absence. The presence of homologs correlates with genome size, with obligate symbionts lacking many of the genes found on the ‘Candidatus S. adelgidicola' genome fragment. * Indicates pseudogenes in ‘Candidatus S. adelgidicola' it must be noted that more distant homologs of IlvL and WaaL are present in E. coli; Ec=Escherichia coli K-12 substr. MG1655 (NC_000913), Sg=Sodalis glossinidius str. ‘morsitans' (NC_007712), Ss=Serratia symbiotica str. Tucson (AENX00000000), Hd=‘Candidatus Hamiltonella defensa 5AT' (Acyrthosiphon pisum) (NC_012751), Bp=‘Candidatus Blochmannia pennsylvanicus str. BPEN' (NC_007292), Wg=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis (NC_004344), Bc=Baumannia cicadellinicola str. Hc (Homalodisca coagulata) (NC_007984), Ba=Buchnera aphidicola str. APS (Acyrthosiphon pisum) (NC_002528), Cr=‘Candidatus Carsonella ruddii PV' (NC_008512).