Table 6.
Published TBS (biphasic pulses) and QPS (monophasic pulses) protocols on normal subjects. No significant side effects reported, apart vagal reactions after prefrontal cortex stimulation. Consensus reached for this table.
| Pulses in the burst | Total train pulses | Intensity | Stimulation site | |
|---|---|---|---|---|
| “Standard” cTBS (following Huang et al. 2005) | 3 at 50 Hz, repeated at 5 Hz | 600 (40 s) | 80% of active MT | Motor cortex, PFCc |
| Silvanto et al. 2007 | 8 at 40 Hz, repeated every 1.8 s | 200 | 60% of the maximal stimulator output | Visual cortex |
| Nyffeler et al. 2006 a | 3 at 30 Hz, repeated at 10 Hz | 200 | 80% of resting MT | Frontal eye fields |
| “Standard” iTBS protocols (following Huang et al. 2005) | 3 at 50 Hz, repeated at 5 Hz for 2 s | 600 | 80% of active MT | Motor cortex, PFCc |
| QPSb (following Hamda et al., 2008) | 4 (ISI ranging 1.5 ms–1.25 s), repeated every 5 s | 1440 | 90% of active MT | Motor cortex |
a
Also repeated TBS in the same session (at 5, 15, 60, 75 min).
b
2000 maximal total pulse number per day; highest intensity used resting MT (Y. Ugawa, personal communication).
c
PFC = prefrontal cortex (Grossheinrich et al. 2009).