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. 2011 Mar 19;2(3):239–244. doi: 10.18632/oncotarget.242

Figure 5. Schematic illustration of the potential role for the PTEN/PI3K/Akt signaling axis in governing Fbw7-mediated Mcl-1 ubiquitination and destruction.

Figure 5

Loss of PTEN, which leads to aberrant activation of the PI3K/Akt signaling cascade, results in inactivation of GSK3 and a subsequent increase in Mcl-1 expression.