Figure 1.

Time-course analysis of gene expression in Ogg1 knockout mouse skin after UVB exposure. A: Genes up- or down-regulated at 3 and 24 hours after exposure of Ogg1 knockout and wild-type mice to UVB. Dots represent genes with an expression difference of >1.5 or <0.5 times (significant genes) after exclusion of low-intensity microarray signals. Red and blue dots represent up- and down-regulated genes in Ogg1-knockout, respectively, with the number of up- and down-regulated genes indicated in the corresponding color. B: Clusters of up- and down-regulated genes at each time point were categorized based on the trend of up- or down-regulation at 3 and 24 hours after UVB exposure. Schematics are shown for the six clusters, along with the number of genes assigned to each cluster.