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. 2011 Dec;179(6):3056–3065. doi: 10.1016/j.ajpath.2011.08.042

Figure 7.

Figure 7

Proposed relationships of versican in the inflammatory response leading to the development of skin tumors in terms of UVB-induced 8-oxoG accumulation. The accumulation of UVB/ROS-induced 8-oxoG in the skin leads to inflammatory reactions. High versican expression is induced by a highly inflammatory microenvironment with high numbers of infiltrated neutrophils; conversely, neutrophil infiltration induces versican overexpression. More ROS will be generated at the inflammatory sites by neutrophils.