Figure 2.

Gelatinase and collagenase activities in livers of DDR2^−/− and DDR2^+/+ mice after CCl₄ administration. Relative gelatinase (A) and collagenase (B) activities in tissue extracts from DDR2^−/− and DDR2^+/+ livers after 10 or 30 days of treatment with CCl₄. For each time point, enzymatic activity in DDR2^+/+ livers was considered 1. Real-time quantitative analyses on MMP-2, MMP-9, and MMP-13 mRNA induction in DDR2^−/− and DDR2^+/+ livers after 10 days (C) and 30 days (D) of treatment with CCl₄. Results are expressed as a ratio versus RPL13 mRNA. *P < 0.05, significantly different compared with DDR2^+/+ group.