Figure 1.

Lung histopathology after SC challenge. H&E staining of lung sections obtained from mice after saline (A) or nonsensitized (B) or sensitized mice challenged with SC at day 2 (C) or day 5 (D). Accumulation of neutrophils and mononuclear cells is shown within the interstitial compartments, and a predominantly lymphocytic infiltration within the peribronchial regions as indicated by thin arrows, as well as multinucleated giant cells (thicker arrow) and loose epitheloid granulomas within both the interstitial and peribronchial areas in SC-challenged mice. Four to five mice were used per group, and the experiments were repeated twice. Original magnification, ×40. N = 4 to 5; mean (SEM of two experiments).