Figure 3.

A: Type 1 cytokine expression in lung and lung histopathology in IFNγ^−/− mice after SC sensitization and challenge. WT mice were sensitized and challenged with SC as described, and lungs were harvested at day 2 and day 5. Relative expression of IFNγ, TNF-α, and IL-12 p40 was measured by real-time PCR. Error bars indicate mean (SEM of two experiments). B: H&E staining was performed on lung sections harvested from WT and IFN-γ^−/− mice at day 2 after SC challenge. N = 5 in each experiment, repeated twice.