Figure 4.

Lung histopathology and inflammatory cell accumulation in WT and TLR9^−/− mice after SC challenge. WT and TLR9^−/− mice were sensitized and challenged with SC, and lungs were harvested at day 2. H&E staining was performed on lung sections as shown in A and B. C: Lung collagenase digests were performed, and total leukocytes were quantitated in different groups with a hemocytometer. D: Total PMN cells were quantified on cytospins. N = 4 to 5 in each group; experiments were performed twice. *P < 0.05 compared with untreated controls; **P < 0.05 compared with SC challenged WT mice.