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. 2012 Jan 16;209(1):123–137. doi: 10.1084/jem.20111009

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© 2012 Leuschner et al.

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Figure 1. — Monocyte infarct residence time after ischemia. Cell tissue kinetics were studied using flow cytometric analysis (FCM) of heart transplants and BrdU pulse experiments. (A) Schematic set-up of the experiment (n = 16; experiment was performed four times). (B) Dot plots of FCM analysis showing the contribution of donor- and recipient-derived Mo in the infarcted heart at 6, 12, and 24 h after transplantation of the heart. (C) Number of Mo retrieved from digested infarcts on day 3 to 6 after MI by FCM. (D) Fitting of donor Mo (y-axis) over time (x-axis). Red circles indicate individual data, the gray line represents the fit described by the equation. (E) Flow cytometric DAPI staining of Mo in the infarct on day 3 after coronary ligation. (F) FCM analysis of the infarct 24 h after BrdU pulse. Dot plots are gated on Mo. (G) Fold-change in BrdU⁺ Mo and lineage⁺ cells in the heart after MI. Mean ± SEM (n = 3–10 per group, experiment was repeated twice). *, P < 0.05.