Table 4. Association between genome-wide homozygosity and MS susceptibility.

Group	Measure	OR	CI	P-value
Age matched (full sample)	FROH	0.85	0.54, 1.35	0.500
	FROH_pr	0.60	0.21, 1.76	0.355
	Hobs	0.88	0.32, 2.43	0.800
Past lifetime risk (full sample)	FROH	0.65	0.44, 0.97	0.034
	FROH_pr	0.26	0.09, 0.72	0.009
	Hobs	0.72	0.32, 1.64	0.438
Age matched (four NI grandparents)	FROH	0.80	0.47, 1.37	0.416
	FROH_pr	0.77	0.22, 2.64	0.675
	Hobs	0.97	0.28, 3.38	0.962
Past lifetime risk (four NI grandparents)	FROH	0.64	0.41, 1.00	0.051
	FROH_pr	0.30	0.10, 0.89	0.030
	Hobs	0.75	0.29, 1.89	0.536
Age matched (four Orkney grandparents)	FROH	0.78	0.38, 1.63	0.512
	FROH_pr	0.61	0.13, 2.91	0.535
	Hobs	0.57	0.10, 3.21	0.526
Past lifetime risk (four Orkney grandparents)	FROH	0.56	0.29, 1.09	0.089
	FROH_pr	0.18	0.03, 0.99	0.049
	Hobs	0.56	0.53, 1.88	0.345
Age matched (four Shetland grandparents)	FROH	1.26	0.48, 3.29	0.635
	FROH_pr	4.16	0.25, 68.39	0.319
	Hobs	3.18	0.28, 35.60	0.349
Past lifetime risk (four Shetland grandparents)	FROH	0.89	0.42, 1.88	0.765
	FROH_pr	0.61	0.10, 3.90	0.605
	Hobs	1.73	0.27, 10.95	0.559

Abbreviation: NI, Northern Isles of Scotland.