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5-FU loading and in vitro release studies. (A) Efficiency of 5-FU entrapment (%) into PCL NPs as a function of antitumor drug concentration (inset: corresponding 5-FU loading values, %). The lines are guides for the eye and have no other significance. (B) 5-FU release (%) from PCL NPs at 37.0°C ± 0.5°C as a function of incubation time in PBS (pH 7.4 ± 0.1).
Abbreviations: 5-FU, 5-fluorouracil; NPs, nanoparticles; PBS, phosphate-buffered saline; PCL, poly(ε-caprolactone).
