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. 2011 Oct 19;37(3):746–758. doi: 10.1038/npp.2011.252

Figure 4.

Figure 4

Serotonin transporter (SERT)−/− rats show impaired expression of GABAergic markers, modulation by chronic duloxetine treatment. Vesicular transporter (Vgat; a, d), glutamic acid decarboxylase-67 (Gad67; b, e), and GABA A receptor, gamma 2 (GABAA-γ2; c, f) mRNA levels were measured in the hippocampus (a–c), and prefrontal cortex (d–f) of SERT+/+ and SERT−/− rats treated for 21 days with saline or duloxetine, and killed 24 h after the last injection. The data, expressed as a percentage of SERT+/+/saline (set at 100%), are the mean±SEM from at least six independent determinations. *p<0.05, **p<0.01 vs SERT+/+/saline; $p<0.05, $$$p<0.001 vs SERT−/−/saline (two-way analysis of variance (ANOVA) with single contrast post-hoc test (SCPHT)).