Table 4. Variant vs Control IGT Results.
| Region | L/R |
Talairach coordinates |
Peak t | Cluster size | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Comparison group | ||||||
| vmPFC (BA 47) | L-R | 18 | 32 | −28 | 4.36 | 1834 |
| Anterior cingulate (BA 32) | M | 4 | 24 | 38 | 5.27 | 761 |
| Cerebellum (tonsil) | R | 20 | −48 | −38 | 4.95 | 281 |
| Cerebellum (pyramid of vermis) | L | −4 | −74 | −28 | 4.96 | 2708 |
| Inf. temporal gyrus (A 20) | R | 50 | −16 | −36 | −4.58 | 195 |
| SMA (BA 31) | L-R | 0 | −20 | 46 | −3.83 | 427 |
| Post-central gyrus (BA 3) | L | −44 | −24 | 58 | −4.70 | 244 |
| Inf. parietal lobule (BA 40) | R | 52 | −26 | 24 | −4.94 | 469 |
| Sup. temporal gyrus (BA 40) | L | −56 | −48 | 20 | −5.46 | 1921 |
| Mid. temporal gyrus (BA 39) | R | 58 | −60 | 12 | −5.79 | 1017 |
| MJ user group | ||||||
| Anterior PFC/vmPFC (BA 10) | R | 36 | 46 | 16 | 5.94 | 6139 |
| Mid. frontal gyrus (BA 6) | R | 36 | 8 | 56 | 4.85 | 712 |
| Cerebellum (inf. semi-lunar lobule) | L | −48 | −68 | −40 | 7.16 | 4236 |
| Precuneus (BA 7) | L-R | −14 | −80 | 50 | 5.37 | 1027 |
| Sup. temporal gyrus (BA 38) | R | 34 | 2 | −46 | −5.20 | 1667 |
| Inf. temporal gyrus (BA 20) | L | −40 | −2 | −36 | −6.81 | 3685 |
| Insula (BA 13) | L | −44 | −4 | 12 | −3.98 | 262 |
| Sup. temporal gyrus (BA 39) | L | −52 | −60 | 18 | −6.16 | 2206 |
| Mid. temporal gyrus (BA 39) | R | 50 | −66 | 10 | −4.88 | 437 |
| Controls > CMJU | ||||||
| Mid. temporal gyrus (BA 38) | L | −40 | 2 | −36 | 4.21 | 399 |
| CMJU > Controls | ||||||
| Insula | L | −34 | −20 | 16 | 4.01 | 270 |
Abbreviations: L, left; M, mesial; R, right.
Note: N=34 (comparison group); N=46 (CMJU group). Significance threshold set at p<0.005 (p<0.05 for vmPFC group comparison); 150 contiguous voxels. In within-group analyses, positive t-values signify greater activity on the gambling task; negative t-values signify greater activity on the control task. A priori vmPFC findings are in bold.