Table 5. Associations with Activity on Variant IGT.
| Region | L/R |
Talairach coordinates |
Peak r | Cluster size | ||
|---|---|---|---|---|---|---|
| x | y | z | ||||
| Correlations with age: controls only | ||||||
| Cuneus (BA 19) | R | 10 | −82 | 30 | −0.54 | 198 |
| Cuneus (BA 18) | L | −14 | −88 | 12 | −0.51 | 190 |
| Correlations with age: users only | ||||||
| Lingual gyrus (BA 18) | R | 10 | −66 | −2 | 0.53 | 236 |
| Mid. tem. gyrus/mid. occ. gyrus (BA 19) | R | 36 | −64 | 16 | 0.58 | 163 |
| vmPFC (BA 10) | M | −2 | 66 | 2 | 0.43 | 666 |
| Sub-genual ACC (BA 10) | M | −14 | 34 | −10 | 0.37 | 329 |
| Correlations with duration of use | ||||||
| Sup. temporal gyrus (BA 22) | R | 64 | −10 | 4 | −0.50 | 405 |
| Lingual gyrus (BA 18) | R | 10 | −68 | 2 | 0.49 | 181 |
| vmPFC (BA 10) | M | 0 | 66 | 4 | 0.37 | 464 |
| Sub-genual ACC (BA 10) | M | −10 | 34 | −14 | 0.36 | 215 |
| Correlations with first use | ||||||
| Inf. parietal lobule (BA 40) | R | 40 | −34 | 30 | −0.54 | 222 |
| Precuneus (BA 19/39) | R | 30 | −62 | 38 | −0.54 | 208 |
| Post-central gyrus (BA 43) | R | 62 | −16 | 20 | 0.47 | 154 |
| Insula (BA 13) | L | −46 | −4 | 14 | 0.54 | 152 |
Note: N=46. Significance threshold set at p<0.005 (p<0.05 for vmPFC); 150 contiguous voxels. Positive t-values signify positive correlations; negative t-values signify negative correlations. Correlations are with activity during variant IGT v. control IGT. A priori vmPFC findings are in bold.