Fig. 7.

An illustration summary of our results. PICs released from the site of ischemic injury in the heart enter the CVOs through the circulation, and are subsequently carried/signal to the PVN and VLM, causing release of additional PICs and neurohormones. These molecules further lead to an imbalance of superoxide and NO and activate the c-Jun/JNK/c-Fos pathway and alter gene expression, ultimately resulting in enhanced sympathoexcitation and adverse cardiac remodeling