Table 2. Genes involved in cellular protection found upregulated at mRNA level in HEK-499 RKIP depleted cells.
| Cellular Function | Gene name (Gene symbol) | Expression fold-increase | P value* |
| Antioxidant proteins | Glutamate-cysteine ligase, modifier (GCLM) subunit | 3.15 | 0.009 |
| Glutathione peroxidase 3 (GPX3) | 3.03 | 0.028 | |
| Glutathione reductase (GSR) | 2.63 | 0.0026 | |
| Glutathione synthetass (GSS) | 3.35 | 0.0046 | |
| NAD(P)H dehydrogenase, quinone 1 (NQO1) | 2.7 | 0.01 | |
| NAD(P)H dehydrogenase, quinone 2 (NQO2) | 4.1 | 0.005 | |
| Thioredoxin (TXN) | 2.2 | 0.003 | |
| Thioredoxin reductase 3 (TXNRD3) | 2.5 | 0.0002 | |
| NADPH regeneration enzyme | Malic enzyme 1 | 6.3 | 0.001 |
| Phase I drug oxidation, reduction and hydrolysis | Aldo-keto reductase (AKR) 1B | 2.3 | 0.02 |
| Aldo-keto reductase (AKR) 7A3 | 2.25 | 0.001 | |
| Aldo-keto reductase (AKR) 7A2 | 4.63 | 0.0003 | |
| Carbonyl reductase 1 (CR1) | 3.4 | 0.025 | |
| Epoxide hydrolase 2 cytoplasmic (EPHX2) | 2 | 0.001 | |
| Phase II drug conjugation | Glutathione S-transferase A4 (GSTA4) | 2.8 | 0.0003 |
| Glutathione S-transferase (GSTP1) class pi | 2.86 | 0.005 | |
| Glutathione S-transferase omega 1 | 3.65 | 0.001 | |
| Glutathione transferase zeta 1 (GSTZ1, maleylacetoacetate isomerase) | 2.7 | 0.001 | |
| Glutathione S-transferase M3 (GSTM3 brain†) | 3.1 | 0.0006 | |
| Microsomal glutathione S-transferase (MGST) 1 | 6.8 | 0.009 | |
| Microsomal glutathione S-transferase (MGST) 2 | 2.24 | 0.002 | |
| Microsomal glutathione S-transferase (MGST) 3 | 2.3 | 0.001 | |
| Transport | Multi-drug resistance-associated protein (Mrp4) ABCC4 | 3.8 | 0.01 |
| Multi-drug resistance-associated protein (Mrp6) ABCC6 | 4 | 0.02 | |
| Solute carrier family 1(SLC1A5, Neutral amino acid transporter) | 2.1 | 0.013 | |
| Solute carrier family 2 | 2.2 | 0.03 | |
| Solute carrier family 6 | 2.9 | 0.0003 | |
| Solute carrier family 39 | 2.1 | 0.0003 | |
| Chaperones | Hsp40 (DnaJ) | 3.4 | 0.00002 |
| Growth factors | Fibroblast growth factor 13 (FGF 13) | 4.44 | 0.0001 |
| peroxiredoxin family 1–5 (PRDX) | 3.6 | 0.001 | |
| Transforming growth factor β receptor (TGFBR3) | 3.01 | 0.01 | |
| Transcription factors | v-maf musculoaponeurotic fibrosarcoma oncogene homolog avian (MAF) | 3.4 | 0.03 |
| Peroxisome proliferator activated receptor delta (PPARD) | 2.8 | 0.013 |
*ANOVA statistics was used to compare probe intensity means between test and control samples.