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. 2012 Jan 18;7(1):e29848. doi: 10.1371/journal.pone.0029848

Figure 3. The Manhattan plot displays the maximum log10(Bayes Factor) (y-axis) for each of the analyzed SNPs in the discovery set. The Manhattan plot displays the maximum log10(Bayes Factor) (y-axis) for each of the analyzed SNPs in the discovery set.

Figure 3

The SNPs are ordered by chromosome (alternate color bands) and, within chromosome, by physical position (x-axis). We tested the association of each SNP with exceptional longevity using general, allelic, dominant and recessive models and the y-axis reports the maximum log10(Bayes factor) observed for each SNP. The SNP rs2075650 in APOE/TOMM40 reached irrefutable genome wide significance (log10(MBF) = 7.9 and p-value<e-10). Figure S3 shows the Manhattan plot and QQ plot for the additive model using logistic regression.