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. Author manuscript; available in PMC: 2012 Jan 18.
Published in final edited form as: Sci Transl Med. 2011 Jun 8;3(86):86ra51. doi: 10.1126/scitranslmed.3002093

Fig. 4.

Fig. 4

Posttransplant activation/expansion of donor-specific TMEMs. TMEMs were collected from the peripheral blood of recipients before transplantation and at different time points after combined bone marrow/kidney transplantation. The frequencies of IFN-γ–producing TMEMs recognizing donor MHC antigens directly were determined by ELISPOT. The results are expressed as numbers of cytokine-producing cells per million TMEMs. Direct memory alloresponses were assessed in four tolerant recipients (solid lines and dots) and two acutely rejecting monkeys (dotted lines and open symbols). In addition, memory alloreactivity was monitored in a control recipient, which received no immunosuppressive and conditioning treatment before transplantation and underwent acute rejection within 6 days after the placement of an allogeneic kidney (gray line and symbols).