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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Cancer Res. 2011 Nov 29;72(2):402–407. doi: 10.1158/0008-5472.CAN-11-2464

Figure 3. Perfusion Response to Treatment and Survival analysis.

Figure 3

(A) Three types of perfusion response to anti-angiogenic treatment are evident: perfusion increase, stable perfusion or perfusion decrease. Figure show log-scaled averaged values (±SEM) and P-values from Kruskal-Wallis tests (Holm-Bonferroni corrected). Values at day −1 were set as 100%. (B) Kaplan-Meier analysis for progression-free survival. (C) Kaplan-Meier analysis for overall survival. Patients with an increase in tumor perfusion had prolonged PFS compared patients with stable perfusion, and prolonged OS compared to patients with stable and decreased perfusion (Mann-Whitney; P<0.01, Holm-Bonferroni corrected). Differences between PFS and OS may be attributed to the inherent uncertainty of the PFS estimate by the Macdonald criteria – since anti-VEGF agents decrease vascular permeability resulting in decreased contrast in the absence of an anti-tumor effect4.