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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: NMR Biomed. 2011 Jul 20;25(2):195–209. doi: 10.1002/nbm.1730

Figure 5.

Figure 5

CCSI acquired at 3T in 8:32 min using COSY-LASER-SPIRAL in a healthy volunteer. A VOI (8×8 cm2, 2.5cm slice thickness, blue rectangle) is selected by LASER in centrum semiovale above the ventricles (no OVS was used around the skull). The same acquisition parameters and processing methods as in Fig. 4 were employed. The 4×4 voxels (each 10 ml) inside the VOI are shown together with an enlarged spectrum from a central voxel (red outlined). Crosspeaks of several metabolites can be clearly identified: NAA, Cho, Glu, GABA, Myo, GPC (Glycerophosphocholine), PC (Phosphocholine), PE (Phosphoethanolamine), and Threonine (Thr). In particular, resolving the total choline peak (Cho, GPC, PC) and GABA peak can be realized. f1 and f2 projections through the glutamate crosspeak indicate the quality of 2D spectra (SNR and baseline). 1D spectrum from the first t1 increment is shown for comparison.