Kaplan-Meyer survival analysis comparing patients with and without vascular invasion. The median survival for patients with vascular invasion (N=137) was significantly shorter (median survival, 12.9 months; 1-year survival rate, 66.0%; 3-year survival rate, 14.2%) than those without vascular invasion (N=72; median survival time, 17.6 months; 1-year survival rate, 67.8%; 3-year survival rate, 31.7%; log-rank test, p=0.01).