Table II.
Male static and dynamic tibia histomorphometry after five and eight weeks of risperidone treatment.
| Five Week Treatment | Eight Week Treatment | |||||
|---|---|---|---|---|---|---|
| Control (n=6–8) |
Risperidone (n=8) |
p value | Control (n=7–8) |
Risperidone (n=8) |
p value | |
| BV/TV (%) | 8.8 ± 0.4 | 7.3 ± 0.5* | 0.03 | 9.9 ± 1.1 | 6.9 ± 0.7* | 0.03 |
| Tb.Th (µm) | 29.9 ± 1.2 | 27.2 ± 1.0 | 0.10 | 31.3 ± 1.2 | 28.5 ± 0.9 | 0.09 |
| Tb.N (/mm) | 2.95 ± 0.12 | 2.66 ± 0.12 | 0.11 | 3.12 ± 0.22 | 2.38 ± 0.19* | 0.03 |
| Tb.Sp (µm) | 313 ± 15 | 353 ± 16 | 0.09 | 301 ± 24 | 415 ± 42* | 0.03 |
| MS/BS (%) | 27.7 ± 4.2 | 23.2 ± 2.1 | 0.32 | 26.3 ± 2.5 | 27.6 ± 2.3 | 0.71 |
| MAR (µm/day) | 2.03 ± 0.09 | 2.11 ± 0.18 | 0.72 | 1.18 ± 0.08 | 1.02 ± 0.07 | 0.15 |
| BFR/BS (µm3/µm2/year) | 199 ± 24 | 180 ± 22 | 0.57 | 113 ± 14 | 103 ± 13 | 0.61 |
| BFR/BV (%/year) | 1301 ± 150 | 1273 ± 146 | 0.90 | 706 ± 61 | 741 ± 113 | 0.78 |
| BFR/TV (%/year) | 117 ± 17 | 92 ± 10 | 0.21 | 76 ± 14 | 49 ± 7 | 0.13 |
| Ob.S/BS (%) | 5.2 ± 1.1 | 6.5 ± 1.3 | 0.43 | 2.3 ± 0.6 | 3.0 ± 1.0 | 0.53 |
| N.Ob/T.Ar (/mm2) | 26.2 ± 4.9 | 28.9 ± 4.9 | 0.70 | 12.2 ± 3.2 | 11.2 ± 3.0 | 0.81 |
| N.Ob/B.Pm (/mm) | 4.6 ± 1.0 | 5.4 ± 0.8 | 0.57 | 2.1 ± 0.5 | 2.4 ± 0.7 | 0.78 |
| OV/TV (%) | 0.044 ± 0.011 | 0.047 ± 0.011 | 0.89 | 0.012 ± 0.004 | 0.015 ± 0.006 | 0.63 |
| OS/BS (%) | 3.2 ± 0.8 | 3.3 ± 0.7 | 0.89 | 0.8 ± 0.3 | 1.6 ± 0.6 | 0.24 |
| O.Th (µm) | 2.1 ± 0.3 | 2.5 ± 0.2 | 0.35 | 2.7 ± 0.4 | 1.6 ± 0.4 | 0.08 |
| Oc.S/BS (%) | 2.5 ± 0.6 | 5.7 ± 0.9* | 0.01 | 1.5 ± 0.3 | 2.9 ± 0.5* | 0.02 |
| N.Oc/T.Ar (/mm2) | 6.4 ± 1.6 | 11.8 ± 1.2* | 0.02 | 3.3 ± 0.6 | 5.2 ± 0.9 | 0.11 |
| N.Oc/B.Pm (/mm) | 1.1 ± 0.3 | 2.3 ± 0.3* | 0.01 | 0.6 ± 0.1 | 1.1 ± 0.1* | 0.01 |
| ES/BS (%) | 0.98 ± 0.20 | 2.56 ± 0.38* | <0.01 | 0.53 ± 0.14 | 0.93 ± 0.27 | 0.21 |
*
p<0.05 by two-tailed Student’s t-test.
Abbreviations: BV, bone volume; TV, tissue volume; Tb., trabecular; N, number; Th, thickness; Sp, separation; MS, mineralizing surface; BS, bone surface; MAR, mineral apposition rate; BFR, bone formation rate; Ob.S, osteoblast surface; N.Ob, number of osteoblasts; T.Ar, tissue area; B.Pm, bone perimeter; OV, osteoid volume; OS, osteoid surface; O.Th, osteoid thickness; Oc.S, osteoclast surface; N.Oc, number of osteoclasts; ES, eroded surface.