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. Author manuscript; available in PMC: 2013 Jan 13.
Published in final edited form as: Chem Res Toxicol. 2011 Nov 16;25(1):113–121. doi: 10.1021/tx200272v

Figure 1.

Figure 1

PAH o-quinones are less cytotoxic than PAH diols and PAH diol epoxides to A549 cells. A) A549 cells were seeded at density of 1.0 × 105 cells per well and allowed to attach for 24 hrs. Cells were then treated with varying concentrations of anti-BPDE, B[a]P-7,8-trans-dihydrodiol (Diol) and B[a]P-7,8-dione (BPQ) for 24 hrs, trypsinized and counted using the trypan blue exclusion method. B–C) Cell viability of A549 cells treated with (B) DMBAQ and DMBADE (C) BAQ and BADE for 24 hrs. D) A549 cells were treated with different concentrations of BPQ and anti-BPDE and allowed to grow for 72 hours. At each time point cells were trypsinized and counted using trypan blue exclusion method. Results are the mean of three independent experiments.