Table 3.
Hazard ratio (HR) and 95% confidence intervals (95% CI) of dying from the actual cancer disease by quartile groups of 25-OHD for all cancer patients combined (A) and by cancer-specific quartile groups of 25-OHD (B)
| Breast | Colon | Lung | Lymphoma | |
|---|---|---|---|---|
| HR (95% CI)** | HR (95% CI)** | HR (95% CI)** | HR (95% CI)** | |
| (A) | ||||
|
1. Quartile (<46 nmol/L) |
1.00 reference 22/45* |
1.00 reference 8/13* |
1.00 reference 59/63* |
1.00 reference 20/40* |
|
2. Quartile (46–61 nmol/L) |
0.60 (0.33, 1.09) 22/62* |
0.53 (0.17, 1.64) 6/12* |
0.39 (0.26, 0.58) 49/62* |
0.61 (0.31, 1.20) 16/34* |
|
3. Quartile (62–81 nmol/L) |
0.43 (0.22, 0.82) 16/58* |
0.60 (0.20, 1.79) 8/17* |
0.34 (0.22, 0.53) 36/44* |
0.44 (0.22, 0.88) 15/43* |
|
4. Quartile (>81 nmol/L) |
0.41 (0.22, 0.78) 22/86* |
0.37 (0.08, 1.81) 4/10* |
0.18 (0.11, 0.29) 29/41* |
0.38 (0.17, 0.83) 11/28* |
| p for trend | p = 0.01 | p = 0.27 | p < 0.01 | p = 0.02 |
| (B) | ||||
| 1. Quartile*** |
1.00 reference 22/45* |
1.00 reference 8/13* |
1.00 reference 59/63* |
1.00 reference 20/40* |
| 2. Quartile*** |
0.47 (0.26, 0.85) 22/62* |
0.46 (0.15, 1.48) 6/12* |
0.37 (0.24, 0.57) 49/62* |
0.71 (0.36, 1.40) 16/34* |
| 3. Quartile*** |
0.53 (0.29, 0.95) 16/58* |
0.73 (0.25, 2.15) 8/17* |
0.35 (0.23, 0.54) 36/44* |
0.45 (0.21, 0.94) 15/43* |
| 4. Quartile*** |
0.42 (0.21, 0.82) 22/86* |
0.20 (0.04, 1.10) 4/10* |
0.18 (0.11, 0.29) 29/41* |
0.39 (0.18, 0.83) 11/28* |
| p for trend | p = 0.01 | p = 0.16 | p < 0.01 | p = 0.01 |
* Number of fatal cases/Number of patients
** Adjusted for sex, age at diagnosis and season of blood sampling
*** Quartile limits: Breast 50, 67, 86 nmol/L; Colon 44, 56, 77 nmol/L; Lung 41, 56, 76 nmol/L; Lymphoma 44, 60, 77 nmol/L