. 2011 Dec 23;23(2):363–370. doi: 10.1007/s10552-011-9885-6

Table 4.

Hazard ratio (HR) and 95% confidence intervals (95% CI) of dying from the actual disease in breast, colon, and lung cancer patients stratified by stage of disease at the time of diagnosis, in quartile groups of 25-OHD

	Localized	Regional	Distant	Unknown
1. Quartile (<46 nmol/L)	1.00 reference 4/12*	1.00 reference 31/43*	1.00 reference 43/49*	1.00 reference 11/17*
2. Quartile (46–61 nmol/L)	0.39 (0.10, 1.59) 8/29*	0.48 (0.27, 0.83) 23/46*	0.73 (0.45, 1.20) 31/35*	0.69 (0.30, 1.58) 15/26*
3. Quartile (62–81 nmol/L)	0.34 (0.09, 1.36) 6/24*	0.39 (0.22, 0.71) 20/36*	0.39 (0.23, 0.66) 25/33*	0.42 (0.16, 1.05) 9/26*
4. Quartile (>81 nmol/L)	0.15 (0.03, 0.89) 4/35*	0.29 (0.15, 0.53) 20/49*	0.38 (0.22, 0.66) 20/25*	0.39 (0.16, 0.98) 11/28*
p for trend	p = 0.06	p < 0.01	p < 0.01	p = 0.04

Localized

Regional

Distant

Unknown

HR (95% CI)**

1. Quartile

(<46 nmol/L)

1.00 reference

4/12*

1.00 reference

31/43*

1.00 reference

43/49*

1.00 reference

11/17*

2. Quartile

(46–61 nmol/L)

0.39 (0.10, 1.59)

8/29*

0.48 (0.27, 0.83)

23/46*

0.73 (0.45, 1.20)

31/35*

0.69 (0.30, 1.58)

15/26*

3. Quartile

(62–81 nmol/L)

0.34 (0.09, 1.36) 6/24*

0.39 (0.22, 0.71)

20/36*

0.39 (0.23, 0.66)

25/33*

0.42 (0.16, 1.05)

9/26*

4. Quartile

(>81 nmol/L)

0.15 (0.03, 0.89)

4/35*

0.29 (0.15, 0.53)

20/49*

0.38 (0.22, 0.66)

20/25*

0.39 (0.16, 0.98)

11/28*

p for trend

p = 0.06

p < 0.01

p = 0.04

* Number of fatal cases/Number of patients

** Adjusted for sex, age at diagnosis, and season of blood sampling