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. 2011 Nov 11;463(2):365–376. doi: 10.1007/s00424-011-1045-z

Table 1.

E-4031 does not affect cell proliferation

Cell line IHERG (pA/pF), n/n+ Cell proliferation
24 h 48 h 72 h
SW2 31.7 ± 2.5, 22/25 Control, 1 μM E-4031; 5 μM E-4031 1.00 ± 0.05; 0.92 ± 0.03; 0.99 ± 0.02 1.00 ± 0.05; 0.86 ± 0.04; 0.90 ± 0.06 1.00 ± 0.03; 0.89 ± 0.06; 0.84 ± 0.04
OH1 13.2 ± 2.8, 5/7 Control, 1 μM E-4031; 5 μM E-4031 1.00 ± 0.01; 0.98 ± 0.02; 1.00 ± 0.05 1.00 ± 0.06; 0.96 ± 0.06; 0.84 ± 0.05 1.00 ± 0.02; 0.96 ± 0.02; 0.92 ± 0.05
OH3 34.5 ± 2.7, 4/6 Control, 1 μM E-4031; 5 μM E-4031 1.00 ± 0.03; 0.97 ± 0.04; 0.92 ± 0.01 1.00 ± 0.08; 0.93 ± 0.07; 0.92 ± 0.09 1.00 ± 0.05; 0.85 ± 0.03; 0.91 ± 0.05
H82 12.7 ± 0.8, 3/5 Control, 1 μM E-4031; 5 μM E-4031 1.00 ± 0.02; 1.04 ± 0.14; 0.97 ± 0.09 1.00 ± 0.10; 1.03 ± 0.18; 1.37 ± 0.10 1.00 ± 0.05; 1.11 ± 0.20; 1.09 ± 0.13

Cell proliferation of four SCLC cell lines (SW2, OH1, OH3, H82) measured after 24, 48, and 72 h in the presence of 1 or 5 μM E-4031 normalized to the corresponding control cells in the absence of E-4031 (mean ± SEM). Each mean value was calculated from six to nine measurements. There was no statistically significant change in cell proliferation as compared with the control cells by using the t-test and the Bonferroni correction

n number of cells containing HERG current, n+ total number of cells investigated