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Expression confirmed in midbrain VTA of proestrous rats for pregnane xenobiotic receptor (PXR) and biosynthesis and metabolism proteins/enzymes required for 3α,5α-THP formation [steroid acute regulatory protein (StAR), P450 side chain cleavage enzyme (P450scc), 5α-reductase, and 3α-hydroxysteroid dehydrogenase (3α-HSD)].
| PXR | StAR | P450scc | 5α-Reductase | 3α-HSD | |
|---|---|---|---|---|---|
| mRNA on microarray | ✓ | ✓ | ✓ | ✓ | ✓ |
| mRNA confirmed with qPCR | ✓ | ✓ | ✓ | ✓ | ✓ |
| Protein on westerns | ✓ | ✓ | ✓ | ✓ | ✓ |
