Fig. 3.

Effects of p38 MAPK activation or inhibition with sodium arsenite (SA) or SB-203580 (SB) on H₂O₂-induced TNF-α generation. RCM were pretreated with vehicle, 5 μmol/L SB for 1 h followed by treatment with 100 μM SA for 15 min followed by 100 μmol/L H₂O₂ for an additional 15 min. Representative Western blots (a) and cumulative data (b) are shown. Data are results of 3 independent experiments and are expressed relative to untreated cells; *P < 0.05 as compared with control, ^#P < 0.05 compared H₂O₂-treated group