Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustration of the stepwise recruitment of SWI/SNF to MyoD-target genes by pre-assembled BAF60c–MyoD complex. In undifferentiated myoblasts, myogenin promoter is bound by MyoD and BAF60c, in the absence of Brg1-based SWI/SNF core complex. SWI/SNF core is recruited to the promoter by differentiation-activated p38 kinase α/β, through phosphorylation of BAF60c on threonine 229, thereby promoting chromatin remodelling and assembly of the transcriptosome for initiation of transcription.
