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Seizures moderately suppress firing to prolonged 1s current injections. (a) Representative whole cell current clamp tracings to 1 s current injections. (b) Cumulative probability plot of firing in both wildtype and mLGI1 neurons with or without a seizure. (c) Threshold current to fire significantly (2-way ANOVA) increases following a seizure (F(1,25)=6.88, p = 0.015), with no effect of genotype (F(1,25)=0.16, p = 0.78), and no seizure-genotype interaction(F(1,25)=0.08, p = 0.68).
