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. 2011 Nov 22;106(2):366–374. doi: 10.1038/bjc.2011.520

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Copyright © 2012 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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PAI-1 and miR-143/-145 expression in clinical bladder specimens. (A) White background: overview of bladder cancer stage classification. Grey background: description of cell lines used in this study placed next to tumour grade origin (adapted from Wiklund et al (2011)). (B) Graphical depiction of the PAI-1 and miR-143/-145 genomic loci. (C) Affymetrix exon array relative PAI-1 expression in normal bladder tissues (n=9), Ta tumours (n=49), T1 tumours (n=8) and T2–T4 tumours (n=34). (D and E) Exiqon LNA array relative expression of miR-143 and -145 in normal bladder tissues (n=11), Ta tumours (n=30), T1 tumours (n=47) and T2-T4 tumours (n=27; adapted from Dyrskjot et al (2009)). (F) Scatter plot analysis of miR-143/-145 expression correlation in the bladder samples from (D and E; P=5.6E-33). (^*P<0.05, ^**P<0.01, ^***P<0.001 compared with all other groups individually or as indicated with bridging bars. Rounded dots in box plots indicate maximum outliers. P-values determined by 2-tailed Student's t-test).