Table 5b. Seminomas and non-seminoma testicular samples: (b) analysis of gene panels, based on logistic regression model, considering optimal cutoff for differenciating both groups.
| Combined genes | Cutoff based on predictive probability of tumor a | Sensitivity (%) | Specificity (%) | AUC (95% CI) |
|---|---|---|---|---|
| APC | 0.3644 | 78.6 (49.2–95.3) | 90.7 (77.9–97.4) | 0.87 (0.74–0.99) |
| APC, MLH1, ER-β and FKBP4 | 0.124726 | 85.7 (57.2–98.2) | 93.0 (80.9–98.5) | 0.90 (0.81–1.00) |
Abbreviations: AUC=area under the curve; CI=confidence interval.
a
Predictive probabilities were obtained from the logistic regression models.