Table 3. Number of risk alleles and breast cancer risk for (a) 10a SNP analysis and (b) 7b SNP analysis.

	Cases		Controls		OR (95% CI)	OR (95% CI)
No. of risk alleles	N	%	N	%	Breast cancer	Breast cancer
(a)
					Reference=8 risk allelesc	Reference ⩽6 risk alleles
⩽6	521	14.5	983	19.4	0.80 (0.69–0.92)	1
7	494	13.8	831	16.4	0.90 (0.77–1.04)	1.12 (0.96–1.31)
8	641	17.9	966	19.1	1	1.25 (1.08–1.45)
9	662	18.5	873	17.2	1.14 (0.99–1.32)	1.43 (1.24–1.66)
10	555	15.5	682	13.5	1.23 (1.06–1.42)	1.54 (1.32–1.79)
⩾11	711	19.8	728	14.4	1.47 (1.27–1.70)	1.84 (1.59–2.14)
						P-trend: 5.6 × 10−20
(b)
					Reference=5 risk allelesc	Reference ⩽3 risk alleles
⩽3	438	12.2	916	18.1	0.67 (0.58–0.78)	1
4	539	15.0	929	18.3	0.81 (0.71–0.94)	1.21 (1.04–1.42)
5	759	21.2	1065	21.0	1	1.49 (1.29–1.73)
6	723	20.2	963	19.0	1.05 (0.92–1.20)	1.57 (1.35–1.82)
7	586	16.4	659	13.0	1.25 (1.08–1.44)	1.86 (1.59–2.18)
⩾8	539	15.0	531	10.5	1.42 (1.22–1.66)	2.12 (1.80–2.50)
						P-trend: 1.5 × 10−25

Abbreviations: CI=confidence interval; OR=odds ratio; SNP=single-nucleotide polymorphism.

^ars2981582, rs3803662, rs889312, rs13281615, rs3817198, rs981782, rs13387042, rs4666452, rs30099 and rs1045485.

^brs2981582, rs3803662, rs889312, rs13281615, rs3817198, rs981782 and rs13387042

^cMedian number of risk alleles.