Table 2.

Changes of patient complaints, mean tear film break-up time (±SD) and abnormal corneal fluorescein staining at baseline (latanoprost), 2, 6, and 12 weeks after changing medication to preservative-free tafluprost

	Baseline	Week 2	Week 6	Week 12	P-value (12 weeks vs baseline)
Dry eye complaints n = 30 (patients)	30 (100%)	19 (63.3%)	11 (36.7%)	11 (36.7%)	<0.05 (McNemar)
Tear film break-up time (seconds) n = 60 (eyes)	3.7 ± 1.1	4.1 ± 1.0	5.2 ± 1.5	6.5 ± 1.5	<0.001 (paired t-test)
Abnormal fluorescein staining of the cornea n = 60 (eyes)	45 (75.0%)	35 (58.3%)	21 (35%)	7 (12%)	<0.005 (McNemar)

Abbreviation: SD, standard deviation.