Figure 8.

The proportion of type I and type II T47D cells is dependent on TRAIL concentration. (A) Positions of the separatrix in the [XIAP] versus [caspase-3] dimensions under conditions in which ligand, caspase-8, or receptor levels were changed as indicated (fold decrease or increase from the baseline; see Materials and methods). The type I region widens as the separatrix shifts toward the [XIAP] axis. (B) TRAIL dose response. Graphs show the fraction of dying T47D cells that are WT or OE-Bcl2 (lower panel) as calculated from a dose-response curve to TRAIL concentration + 2.5 μg/ml CHX (upper panel). Error bars report the standard deviation of biological triplicates from one representative experiment. Source data is available for this figure in the Supplementary Information.

Source Data for Figure 8B ^{(20.5KB, xls)}