Figure 1.

Lineage-specific expansion of the TFB family in Archaea. Phylogenetic analysis of TFB proteins in Archaea highlights the extent of lineage-specific expansion particularly in halophilic archaea. Amino-acid sequences for TFBs from 82 complete archaeal genome sequences (MicrobesOnline (Dehal et al, 2010)) were aligned with MUSCLE (Edgar, 2004) and a phylogenetic tree was constructed as described in Materials and methods. Branches belonging to the same phylum and class are colorized based on taxonomy using Archaeopteryx (Han and Zmasek, 2009) and iTOL (Letunic and Bork, 2011). Tree is outlined with the same colors to highlight expansions in the similar class ranges. Color code for each class, corresponding phylum, number of genomes (red color), and number of proteins (blue color) are given in the legend. Halophilic archaeal TFBs are highlighted in blue background. Sequences used in this analysis are listed in Supplementary Table S1.