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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Cell. 2011 May 13;145(4):529–542. doi: 10.1016/j.cell.2011.03.041

Figure 4. BRCA2 Domain Analysis Reveals Differences in Fork Stability and HDR.

Figure 4

(A) Graphical sketch of human BRCA2, PIR2, and BRC3-RPA. PALB2-interaction site (bright green), BRC repeats (dark green bars), DNA binding domain (DBD, black bar), C-terminal region (C-ter) with non-BRC RAD51 binding site (red bar). Arrows indicate truncations in V-C8 cells.

(B–C) IdU tracts in V-C8 cells stably expressing the PIR2 (B) or BRC3-RPA (C) peptides with or without HU.