FIGURE 1.
Secondary structure of the ciRNA. At top is a diagram of the poliovirus RNA genome with open reading frames for the viral protein products shown. The ciRNA is found in the 3CPro coding region. (Below) The proposed secondary structure is shown. Regions in gray are not part of the “minimum” functional ciRNA. Various secondary structure elements are colored and labeled, and the kissing interaction is shown with a dashed line and arrows. The WT ciRNA used in this study did not contain any of the RNA in gray.