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. Author manuscript; available in PMC: 2012 Dec 7.
Published in final edited form as: Cell Metab. 2011 Nov 17;14(6):780–790. doi: 10.1016/j.cmet.2011.10.009

Figure 4. MC4R and NPY are necessary for up regulation of Nr1i3 and its target genes during fasting.

Figure 4

Expression of various genes in the liver was measured via QPCR and normalized to Rn18S expression in WT (n = 17, n = 10), Npy−/− (n = 10, n = 7) and pair-fed Mc4r−/− PF (n = 7, n = 7) and DKO PF (n = 9, n = 7) mice. A, Expression of Thrsp and Fasn. B, Expression of Nr1i3 and its classical target gene, Cyp2b10. C, Expression of the Nr1i3-target genes involved in hepatic TH metabolism: Sult1a1, Sult2a1, Sult1d1 and Ugt1a1. D, Expression of Thrβ1. In all panels, data are presented as mean ± SEM. Significance was measured with 2-way ANOVA with Bonferroni post hoc test. * = p < 0.05; ** = p < 0.01; *** = p < 0.001.

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